Resveratrol is a chemical found in red wine, red grape skins, purple grape juice, mulberries, and in smaller amounts in peanuts. Supplementation of resveratrol refers to trans-resveratrol exclusively.
Latest Research
- Resveratrol is effective in inhibiting or reversing salient effects of aging (osteoporosis, sarcopenia, cognitive decline, etc.). [1]
- Lifelong supplementation of resveratrol has been found to increase lifespan and delay biomarkers of Alzheimer's. [2]
- Resveratrol preserves the response to the agents (naturally occurring within the body) that induce relaxation of the blood vessel wall. Relaxation of the vessel wall by these agents tends to be impaired in chronic disease, and resveratrol reverses or attenuates this impairment. [3] [4]
- Resveratrol has been shown to increase insulin sensitivity in obese persons,with lower doses needed for those in worse metabolic condition (insulin resistant, diabetic) and higher doses needed for those in pre-clinical disease states. [5]
- Resveratrol was found to prevent formation of fat cells and increase the rate of the fat breakdown. [6] [7] [8] [9]
- Resveratrol influences bone formation by redirecting the stem cells from becoming fat cells into bone cells, especially in combination with Vitamin D. [10] [11] [12]
- Resveratrol is currently being investigated for usage in hepatic metastasis prevention due to its protective effects against hepatocellular carcinoma proliferation. [13] [14] [15]
- Resveratrol has shown promise on skin cancers when used topically and shows efficacy against esophageal cancer when ingested orally. [16] [17]
- Resveratrol is being investigated in reducing the risk of breast cancers. [18]
Buy Supplement
How to Take
The lower end of supplementation tends to be for cardiovascular health, insulin sensitivity, and longevity for somebody who is otherwise unhealthy is 5-10mg daily. For persons who are otherwise healthy, dosages between the range of 150-445mg have been used (with no clear indication for what is the optimal dose). Supplementing for cerebral blood flow requires a dose in the 250-500mg range.Nutrient-Nutrient Interactions
- Resveratrol works synergistically with other bioflavonoids like Genistein or Quercetin in decreasing fat cell accumulation, and combining all three bioflavonoids showed further synergism. [19] [20] [21]
- Quercetin is synergistic with resveratrol in protection of blood vessels. [22]
- Calcium-D-Glucarate increases anti-oxidative potential and anti-thrombic effects of resveratrol. [23]
- Resveratrol is synergistic with Melatonin in neuroprotection (brain health) and possibly cardioprotection. [24] [25]
- Indole-3-Carbinol augments anti-cancer effects of resveratrol. [26] [27]
- Curcumin synergistically increases effectiveness of resveratrol against lung cancer and osteoarthritis. [28] [29]
Safety Information
Toxicity and Side Effects
Resveratrol is LIKELY SAFE when used in the amounts found in foods. Resveratrol is POSSIBLY SAFE for most people when taken by mouth or applied to the skin in appropriate amounts. In humans, up to 5g have been taken with no side effects outside of some intestinal upset and nausea. Resveratrol in the micronized form at this dosage showed the severity of symptoms decrease, indicating that nausea and intestinal upset are caused by resveratrol's poor bioavailability.Special Precautions And Warnings
Resveratrol might slow blood clotting and increase the risk of bleeding in people with bleeding disorders. Resveratrol might increase the risk of bleeding during and after surgery. Stop using resveratrol at least 2 weeks before a scheduled surgery. Resveratrol might act like estrogen. If you have any condition that might be made worse by exposure to estrogen, don"t use resveratrol.Drug Interactions
- Resveratrol might decrease how quickly the liver breaks down some medications. Taking resveratrol along with such medications may increase the effects and side effects of some medications.
- Resveratrol might slow blood clotting. Taking resveratrol along with medications that also slow clotting might increase the chances of bruising and bleeding. Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.
References
[1] Smoliga JM, Baur JA, Hausenblas HA. Resveratrol and health--a comprehensive review of human clinical trials. Mol Nutr Food Res. (2011)[2] Porquet D, et al. Dietary resveratrol prevents Alzheimer's markers and increases life span in SAMP8. Age (Dordr). (2012)
[3] Küng Christoph F., Lüscher Thomas F. Different Mechanisms of Endothelial Dysfunction With Aging and Hypertension in Rat Aorta. Hypertension (1995)
[4] Rush JW, Denniss SG, Graham DA. Vascular nitric oxide and oxidative stress: determinants of endothelial adaptations to cardiovascular disease and to physical activity. Can J Appl Physiol. (2005)
[5] Timmers S, et al. Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Cell Metab. (2011)
[6] Rayalam S1, Yang JY, Ambati S, Della-Fera MA, Baile CA Resveratrol induces apoptosis and inhibits adipogenesis in 3T3-L1 adipocytes. Phytother Res. (2008)
[7] Szkudelska K, Nogowski L, Szkudelski T. Resveratrol, a naturally occurring diphenolic compound, affects lipogenesis, lipolysis and the antilipolytic action of insulin in isolated rat adipocytes. J Steroid Biochem Mol Biol. (2009)
[8] Baile CA, et al. Effect of resveratrol on fat mobilization. Ann N Y Acad Sci. (2011)
[9] Fischer-Posovszky P, et al. Resveratrol regulates human adipocyte number and function in a Sirt1-dependent manner. Am J Clin Nutr. (2010)
[10] Bäckesjö CM, et al. Activation of Sirt1 decreases adipocyte formation during osteoblast differentiation of mesenchymal stem cells. Cells Tissues Organs. (2009)
[11] Mizutania Kenichi, Ikedac Katsumi, Kawaib Yasuhiro, Yamoria Yukio Resveratrol Stimulates the Proliferation and Differentiation of Osteoblastic MC3T3-E1 Cells. Biochem. Biophys. Res. Commun. (1998)
[12] Lai CY, et al. Preventing bone loss & weight gain with combinations of Vitamin D & phytochemicals. J Med Food (2011)
[13] Delmas D, et al. Inhibitory effect of resveratrol on the proliferation of human and rat hepatic derived cell lines. Oncol Rep. (2000)
[14] Sun ZJ, et al. Anti-hepatoma activity of resveratrol in vitro. World J Gastroenterol. (2002)
[15] Howells LM, et al. Phase I randomized, double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases--safety, pharmacokinetics, and pharmacodynamics. Cancer Prev Res (Phila). (2011)
[16] Athar Mohammad, et al. Resveratrol: A Review of Pre-clinical Studies for Human Cancer Prevention. Toxicol Appl Pharmacol. (2007)
[17] Li Zhi Gang, et al. Suppression of N -nitrosomethylbenzylamine (NMBA)-induced esophageal tumorigenesis in F344 rats by resveratrol. Carcinogenesis (2002)
[18] Wang Y, Ye L, Leung LK. A positive feedback pathway of estrogen biosynthesis in breast cancer cells is contained by resveratrol. Toxicology. (2008)
[19] Rayalam Srujana, et al. Resveratrol Potentiates Genistein's Antiadipogenic and Proapoptotic Effects in 3T3-L1 Adipocytes. J. Nutr. (2007)
[20] Yang JY, et al. Enhanced inhibition of adipogenesis and induction of apoptosis in 3T3-L1 adipocytes with combinations of resveratrol and quercetin. Life Sci. (2008)
[21] Park HJ, et al. Combined effects of genistein, quercetin, and resveratrol in human and 3T3-L1 adipocytes. J Med Food. (2008)
[22] Kleinedler JJ, et al. Synergistic effect of resveratrol and quercetin released from drug-eluting polymer coatings for endovascular devices. J Biomed Mater Res B Appl Biomater. (2011)
[23] Olas B, Saluk-Juszczak J, Wachowicz B. D-glucaro 1,4-lactone and resveratrol as antioxidants in blood platelets. Cell Biol Toxicol. (2008)
[24] Kwon KJ, et al. Melatonin synergistically increases resveratrol-induced heme oxygenase-1 expression through the inhibition of ubiquitin-dependent proteasome pathway: a possible role in neuroprotection. J Pineal Res. (2011)
[25] Lamont KT, et al. Is red wine a SAFE sip away from cardioprotection? Mechanisms involved in resveratrol- and melatonin-induced cardioprotection. J Pineal Res. (2011)
[26] Raj MH, et al. Synergistic action of dietary phyto-antioxidants on survival and proliferation of ovarian cancer cells. Gynecol Oncol. (2008)
[27] Trusov NV, et al. Effects of combined treatment with resveratrol and indole-3-carbinol. Bull Exp Biol Med. (2010)
[28] Malhotra A, Nair P, Dhawan DK. Curcumin and resveratrol synergistically stimulate p21 and regulate cox-2 by maintaining adequate zinc levels during lung carcinogenesis. Eur J Cancer Prev. (2011)
[29] Csaki C, Mobasheri A, Shakibaei M. Synergistic chondroprotective effects of curcumin and resveratrol in human articular chondrocytes: inhibition of IL-1beta-induced NF-kappaB-mediated inflammation and apoptosis. Arthritis Res Ther. (2009)